32,302 research outputs found

    Evaluate ERTS Imagery for Mapping and Detection of Changes of Snowcover on Land and on Glaciers

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    ERTS-1 imagery for mapping and detecting changes in snow cover on land and glacier

    SIMMUNE, a tool for simulating and analyzing immune system behavior

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    We present a new approach to the simulation and analysis of immune system behavior. The simulations that can be done with our software package called SIMMUNE are based on immunological data that describe the behavior of immune system agents (cells, molecules) on a microscopial (i.e. agent-agent interaction) scale by defining cellular stimulus-response mechanisms. Since the behavior of the agents in SIMMUNE can be very flexibly configured, its application is not limited to immune system simulations. We outline the principles of SIMMUNE's multiscale analysis of emergent structure within the simulated immune system that allow the identification of immunological contexts using minimal a priori assumptions about the higher level organization of the immune system.Comment: 23 pages, 10 figure

    The Influence of Safety, Efficacy, and Medical Condition Severity on Natural v. Synthetic Drug Preference

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    Research indicates that there is a preference for natural v. synthetic products, but the influence of this preference on drug choice in the medical domain is largely unknown. We present 5 studies in which participants were asked to consider a hypothetical situation in which they had a medical issue requiring pharmacological therapy. Participants ( N = 1223) were asked to select a natural, plant-derived, or synthetic drug. In studies 1a and 1b, approximately 79% of participants selected the natural v. synthetic drug, even though the safety and efficacy of the drugs were identical. Furthermore, participants rated the natural drug as safer than the synthetic drug, and as that difference increased, the odds of choosing the natural over synthetic drug increased. In studies 2 and 3, approximately 20% of participants selected the natural drug even when they were informed that it was less safe (study 2) or less effective (study 3) than the synthetic drug. Finally, in study 4, approximately 65% of participants chose a natural over synthetic drug regardless of the severity of a specific medical condition (mild v. severe hypertension), and this choice was predicted by perceived safety and efficacy differences. Overall, these data indicate that there is a bias for natural over synthetic drugs. This bias could have implications for drug choice and usage

    Effects of Hyperbaric Hypoxia on Some Enzyme Systems in the Mammalian Liver

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    The metabolic effects of hypobaric hypoxic stress on the mammalian liver were studied. The lactate dehydrogenase (LDH) and succinate dehydrogenase (SDH) activity of mouse liver homogenates were measured after exposure to an equivalent altitude of 36,000 feet and compared to controls kept at zero altitude. After six and twelve hour incubation periods, the altitude exposed samples demonstrated a significantly higher LDH activity than controls. SDH activity remained unchanged from controls after six hours but was significantly lower than controls after a 12 hour exposure to altitude. It is concluded that the changes in enzyme activity reflect a metabolic control mechanism attempting to maintain adequate energy production during periods of exposure to hypobaric hypoxic stress

    Priming God-Related Concepts Increases Anxiety and Task Persistence

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    Research on the relationship between religiosity and anxiety has been mixed, with some studies revealing a positive relation and other studies revealing a negative relation. The current research used an experimental design, perhaps for the first time, to examine anxiety and task persistence during a stressful situation. Christians and Atheists/Agnostics/Others were primed with God-related or neutral (non-God related) concepts before completing an unsolvable anagram task described as a measure of verbal intelligence. The results revealed that the God-related primes increased both task persistence and anxiousness, which suggests that experimentally induced God-related thoughts caused participants to persist longer on a stressful task, but also to feel more anxious after finishing it. No effect of religious affiliation was found, however, indicating that God-related priming affected Christians and non-Christians in a similar fashion

    A hit-and-run Giant Impact scenario

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    The formation of the Moon from the debris of a slow and grazing giant impact of a Mars-sized impactor on the proto-Earth (Cameron & Ward 1976, Canup & Asphaug 2001) is widely accepted today. We present an alternative scenario with a hit-and-run collision (Asphaug 2010) with a fractionally increased impact velocity and a steeper impact angle.Comment: 11 pages, 2 figures, in press in ICARUS note
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